Gonadotropin Inhibitors

Gonadotropin inhibitors encompass a variety of drugs and substances designed to suppress the production or action of gonadotropins - primarily luteinizing hormone (LH) and follicle-stimulating hormone (FSH) - which are key hormones produced by the pituitary gland that regulate reproductive processes. These inhibitors can be used therapeutically to control or manipulate reproductive function for various medical indications, including hormone-sensitive cancers (such as prostate cancer), endometriosis, uterine fibroids, and as part of contraceptive regimens. By inhibiting the production or action of LH and FSH, gonadotropin inhibitors effectively reduce the stimulation of the gonads, leading to decreased production of sex hormones like testosterone and estrogen. This can result in reduced tumor growth in hormone-sensitive cancers or provide contraception through the suppression of ovulation in women. However, the suppression of gonadotropins and subsequent reduction in sex hormone levels can also lead to side effects such as decreased libido, fertility issues, and potential bone density loss. The use of gonadotropin inhibitors, therefore, requires careful consideration and monitoring by healthcare professionals to balance therapeutic benefits with potential risks.