Glucocorticoids are a category of corticosteroids, which are steroid hormones produced in the adrenal cortex. They play a pivotal role in a wide array of physiological processes, including the regulation of glucose metabolism, modulation of the immune system, and helping the body respond to stress. The most well-known naturally occurring glucocorticoid is cortisol, often referred to as the 'stress hormone.' Glucocorticoids exert their effects by entering cells and binding to glucocorticoid receptors, leading to a variety of responses, such as the suppression of inflammatory genes and the activation of anti-inflammatory proteins. While essential for health, the prolonged elevation of glucocorticoids, either due to chronic stress or exogenous administration (such as prednisone therapy for autoimmune diseases), can have adverse effects. These include suppression of the immune response, increased risk of infections, and potential impacts on hormonal balance, such as reduced testosterone synthesis and function. This is due to the inhibitory effects of high glucocorticoid levels on the hypothalamic-pituitary-gonadal (HPG) axis, which can lead to decreased production of gonadotropins and subsequently lower testosterone levels. Understanding the balance and interplay between glucocorticoids and testosterone is crucial for managing conditions that involve chronic inflammation, stress, and hormonal imbalances.