Globulins represent a broad category of globular proteins present in the blood plasma, serving various critical functions within the body. They are primarily categorized into three main groups: alpha, beta, and gamma globulins, each playing distinct roles in bodily processes. Alpha and beta globulins are primarily involved in transporting substances, including lipids, minerals, and vitamins, throughout the bloodstream. They also play a role in blood clotting and inflammation response. Gamma globulins, on the other hand, are immunoglobulins or antibodies that are crucial for the body's immune response, protecting against infections and diseases. Another significant globulin is sex hormone-binding globulin (SHBG), which binds to sex hormones, notably testosterone and estrogen, regulating their bioavailability and activity in the body. The balance and levels of globulins in the blood can provide important diagnostic information, with abnormalities often indicating diseases or conditions such as liver disorders, autoimmune diseases, and infections. Understanding the functions and levels of globulins, including SHBG, is essential for assessing hormonal status and the diagnosis and management of various health conditions.