Eunuchoidism is a medical condition marked by the failure to develop secondary sexual characteristics, which are the physical changes that typically occur during puberty as a result of hormonal changes. This condition is often associated with hypogonadism, a state in which the gonads (testes in males) produce little or no hormones, including insufficient levels of testosterone. In males, characteristics of eunuchoidism can include a lack of facial and body hair, underdeveloped genitalia, increased arm and leg length relative to torso size, and a high-pitched voice. The condition may also be associated with reduced muscle mass, decreased libido, and infertility. Eunuchoidism can result from various causes, including congenital disorders affecting the testes or the pituitary gland, which controls hormone production, as well as acquired conditions that damage the testes or disrupt hormone production. Treatment typically focuses on hormone replacement therapy, particularly testosterone replacement therapy (TRT), to induce the development of secondary sexual characteristics, improve sexual function, and prevent bone loss. Early diagnosis and treatment are crucial for effectively managing the condition and improving the quality of life for individuals with eunuchoidism.