Estrogens are a group of steroid hormones known for their role in the development and regulation of the female reproductive system and the development of secondary sexual characteristics. While estrogens are considered female hormones, they are also present in men, albeit in smaller amounts. In men, estrogens are produced mainly in the adipose tissue through the aromatization of testosterone and androstenedione. Estrogens play several crucial roles in male physiology, including the regulation of libido, erectile function, and the maintenance of healthy sperm. The balance between testosterone and estrogen is vital for men's health; an imbalance, particularly elevated estrogen levels relative to testosterone, can lead to various health issues such as gynecomastia (the development of breast tissue), infertility, and increased risk of cardiovascular diseases. Estrogens also contribute to bone density in both men and women, and imbalances can lead to osteoporosis. Monitoring and managing estrogen levels, therefore, is important in the context of testosterone replacement therapy (TRT) and overall endocrine health. In some cases, aromatase inhibitors are used in men to manage estrogen levels, especially in the context of TRT, to prevent excessive conversion of testosterone to estrogen.