Dihydrotestosterone (DHT)

Dihydrotestosterone (DHT) is an androgen hormone more potent than testosterone, made from testosterone in the body by the action of an enzyme called 5-alpha reductase. DHT plays a crucial role in the development of male characteristics during puberty, including facial and body hair growth, deepening of the voice, and development of the prostate and genitalia. In adults, DHT contributes to male pattern baldness, growth of facial hair, and regulation of oil gland activities in the skin. While DHT is essential for male development, its excess can lead to conditions such as benign prostatic hyperplasia (BPH) and hair loss. Conversely, insufficient DHT during fetal development can result in underdeveloped male genitalia. The balance of DHT is therefore vital for male health. Treatments that reduce DHT levels, such as 5-alpha reductase inhibitors, are used to treat BPH and prevent hair loss, but they can also have side effects, including potential impacts on sexual function and psychological well-being. Understanding the role and regulation of DHT is important for diagnosing and treating conditions associated with its imbalance.