Dehydroepiandrosterone (DHEA) is one of the most abundant circulating steroid hormones in humans, produced mainly by the adrenal glands, and to a lesser extent by the testes and ovaries. It serves as a precursor to both male and female sex hormones, including testosterone and estrogen, meaning that it can be converted into these hormones in the body. DHEA levels in the body typically peak in early adulthood and gradually decline with age, leading to speculation about its role in aging and the potential benefits of DHEA supplementation. In addition to its role as a hormone precursor, DHEA is thought to have a variety of biological effects on its own, including influencing immune function, energy levels, mood, and cognition, although the exact mechanisms and clinical significance of these effects are still under investigation. Supplementation with DHEA has been explored as a treatment for a variety of conditions, including adrenal insufficiency, depression, and osteoporosis, as well as for improving sexual function and overall well-being in older adults. However, the efficacy and safety of DHEA supplementation remain controversial, and more research is needed to fully understand its benefits and risks.