Androgen Replacement Therapy (ART), also commonly referred to as testosterone replacement therapy (TRT), is a medical treatment aimed at restoring testosterone levels in men diagnosed with hypogonadism (low testosterone levels) to a normal range. Hypogonadism can arise from a variety of causes, including genetic abnormalities, testicular injury, infections, chronic health conditions, and aging. ART is available in several forms, including injections, transdermal patches and gels, oral capsules, and subcutaneous pellets, each with its own advantages and considerations. The goal of ART is to improve symptoms related to testosterone deficiency, such as decreased libido, erectile dysfunction, reduced muscle mass and strength, increased body fat, decreased bone density, and mood changes. While ART can significantly improve quality of life and has potential health benefits, it also carries risks and potential side effects, such as increased risk of prostate abnormalities, blood clots, and sleep apnea, among others. Therefore, treatment should be carefully monitored by a healthcare professional, with regular follow-ups to assess testosterone levels, health outcomes, and any adverse effects. The decision to start ART should be based on a combination of symptomatic presentation and biochemically confirmed low testosterone levels, taking into account individual patient health profiles and personal preferences.