Hepatotoxicity is the term used to describe liver damage caused by chemicals, drugs, herbal supplements, or excessive alcohol use. The liver's primary function is to filter toxins from the blood, and it has a remarkable capacity for regeneration and repair. However, certain substances can overwhelm the liver's defenses, leading to cell damage, inflammation, and impaired liver function. Symptoms of hepatotoxicity may include jaundice, abdominal pain, fatigue, and elevated liver enzymes, as detected in blood tests. In the context of testosterone replacement therapy (TRT), it's important to monitor liver function, as some forms of testosterone, especially oral androgens, have been associated with an increased risk of hepatotoxicity. The management of hepatotoxicity involves identifying and discontinuing the use of the offending substance, providing supportive care, and, in some cases, using medication to protect liver cells and support liver function. Early detection and intervention are crucial to prevent long-term liver damage or failure.